Meiotic DNA replication checkpoint control in fission yeast
نویسندگان
چکیده
منابع مشابه
Functions of fission yeast orp2 in DNA replication and checkpoint control.
orp2 is an essential gene of the fission yeast Schizosaccharomyces pombe with 22% identity to budding yeast ORC2. We isolated temperature-sensitive alleles of orp2 using a novel plasmid shuffle based on selection against thymidine kinase. Cells bearing the temperature-sensitive allele orp2-2 fail to complete DNA replication at a restrictive temperature and undergo cell cycle arrest. Cell cycle ...
متن کاملModeling the control of DNA replication in fission yeast.
A central event in the eukaryotic cell cycle is the decision to commence DNA replication (S phase). Strict controls normally operate to prevent repeated rounds of DNA replication without intervening mitoses ("endoreplication") or initiation of mitosis before DNA is fully replicated ("mitotic catastrophe"). Some of the genetic interactions involved in these controls have recently been identified...
متن کاملDNA replication checkpoint control.
The eukaryotic cell cycle comprises two critical phases, DNA replication (S phase) and the subsequent distribution of an equivalent genome to each of two daughter cells at mitosis (M phase). A signal transduction cascade called the replication checkpoint has evolved to ensure that M phase does not occur prior to the completion of S phase. The mitotic regulators targeted by this checkpoint have ...
متن کاملA checkpoint control linking meiotic S phase and recombination initiation in fission yeast.
During meiosis, high levels of recombination initiated by DNA double-strand breaks (DSBs) occur only after DNA replication. However, how DSB formation is coupled to DNA replication is unknown. We examined several DNA replication proteins for a role in this coupling in Schizosaccharomyces pombe, and we show that ribonucleotide reductase, the rate-limiting enzyme of deoxyribonucleotide synthesis ...
متن کاملp56chk1 protein kinase is required for the DNA replication checkpoint at 37C in fission yeast
the timing of mitosis is determined by a gradual change Stefania Francesconi1, Muriel Grenon, in the wee1/cdc25 ratio. This ratio influences the cell size Dominique Bouvier and Giuseppe Baldacci at division and maintains the dependence of mitosis on IFC 1, Institut de Recherche sur le Cancer, CNRS UPR 9044, the completion of DNA replication (Enoch and Nurse, 7 rue Guy Moquet BP 8, 94801 Villeju...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1999
ISSN: 0890-9369
DOI: 10.1101/gad.13.19.2581